Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AM-2282 | - |
Mus musculus | |
AP-24 | apoptotic protease of 24 kDa, is activated during apoptosis and is able to activate L-DNase II | Homo sapiens | |
cathepsin D | an acid protease, can transform LEI into L-DNase II | Homo sapiens | |
intracellular elastase | a neutral protease, can transform LEI into L-DNase II | Homo sapiens | |
additional information | activation is favoured at pH 4 but is increased by a tissue extract | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress | Gallus gallus |
medicine | is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress | Cricetulus griseus |
medicine | is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress | Mus musculus |
medicine | is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress | Homo sapiens |
medicine | is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of the histidine moiety of His 368 completely abolishes endonuclease activity of L-DNase II | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | caspases inhibitors have no effect on acid endonucleases, and no effect on apoptosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | L-DNase II is translocated to the nucleus to meet its new substrate, DNA | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | is cation-independent | Cricetulus griseus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
HeLa cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
L-1210 cell | - |
Mus musculus | - |
lens | during lens cell differentiation | Homo sapiens | - |
additional information | F-258 cell | Rattus norvegicus | - |
retina | is activated during development | Gallus gallus | - |
retina | is activated in light-induced retinal degeneration | Rattus norvegicus | - |
spleen | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + H2O | - |
Homo sapiens | 3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid DNase | - |
Gallus gallus |
acid DNase | - |
Mus musculus |
acid DNase | - |
Homo sapiens |
acid DNase | - |
Rattus norvegicus |
L-DNase II | - |
Gallus gallus |
L-DNase II | - |
Cricetulus griseus |
L-DNase II | - |
Mus musculus |
L-DNase II | - |
Homo sapiens |
L-DNase II | - |
Rattus norvegicus |
LEI-derived DNase II | - |
Gallus gallus |
LEI-derived DNase II | - |
Cricetulus griseus |
LEI-derived DNase II | - |
Mus musculus |
LEI-derived DNase II | - |
Homo sapiens |
LEI-derived DNase II | - |
Rattus norvegicus |
leukocyte elastase inhibitor-derived DNase II | - |
Gallus gallus |
leukocyte elastase inhibitor-derived DNase II | - |
Cricetulus griseus |
leukocyte elastase inhibitor-derived DNase II | - |
Mus musculus |
leukocyte elastase inhibitor-derived DNase II | - |
Homo sapiens |
leukocyte elastase inhibitor-derived DNase II | - |
Rattus norvegicus |