Cloned (Comment) | Organism |
---|---|
the wild-type and mutant enzyme cDNA plasmid are transiently transfected in HCT116 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H295A | the mutant is inactive | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tunicamycin | inhibits the N-linked glycosylation and virtually abolishes the enzyme activity | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
Western blot analysis, the incubation with tunicamycin results in a 37000 Da enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8WZ79 | enzyme activity is reported in all of the human cell lines examined | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | glycosylation is apparently required for maximal enzyme activity | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products | The protein is a single, contiguous polypeptide chain, featuring N-linked sugar moieties and at least one disulfide bridge | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
deoxyribonuclease IIalpha | - |
Homo sapiens |
DNase IIalpha | - |
Homo sapiens |