Literature summary for 3.1.21.8 extracted from

Carlson, K.; Overvatn, A.
Bacteriophage T4 endonucleases II and IV, oppositely affected by dCMP hydroxymethylase activity, have different roles in the degradation and in the RNA polymerase-dependent replication of T4 cytosine-containing DNA (1986), Genetics, 114, 669-685.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	endonuclease IV activity is almost completely inhibited in the presence of very small amounts of hydroxymethylcytosine in the DNA	Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA where cytosine is partially or completely replaced by hydroxymethylcytosine + H2O	Tequatrovirus T4	DNA where cytosine is partially or completely replaced by hydroxymethylcytosine is degraded in vivo by T4 endonuclease II, EC 3.1.21.8, and endonuclease IV, EC 3.1.21.9	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	P07059	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA where cytosine is partially or completely replaced by hydroxymethylcytosine + H2O	DNA where cytosine is partially or completely replaced by hydroxymethylcytosine is degraded in vivo by T4 endonuclease II, EC 3.1.21.8, and endonuclease IV, EC 3.1.21.9	Tequatrovirus T4	?	-	?

Synonyms

Synonyms	Comment	Organism
endonuclease IV	-	Tequatrovirus T4

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Release 2023.1 (January 2023)