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Literature summary for 3.1.21.10 extracted from

  • Agmon, N.; Yovel, M.; Harari, Y.; Liefshitz, B.; Kupiec, M.
    The role of Holliday junction resolvases in the repair of spontaneous and induced DNA damage (2011), Nucleic Acids Res., 39, 7009-7019.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.21.10

Protein Variants

Protein Variants Comment Organism
additional information construction of mms4DELTA and yen1DELTA deletion mutants, and of the double mutant mms4DELTA/yen1DELTA showing high sensitivity to DNA damage and a specific reduction in crossover events. Genetic interactions of mms4DELTA and yen1DELTA, overview Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Synonyms

Synonyms Comment Organism
Holliday junction resolvase
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 Saccharomyces cerevisiae
Mus81/Mms4 complex
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 Saccharomyces cerevisiae
Yen1
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction yeast strains deleted for both YEN1 and MMS4 show a reduction in growth rate, and are very sensitive to DNA-damaging agents. Yeast cells are unable to carry out meiosis in the absence of both resolvases Saccharomyces cerevisiae
physiological function Holliday junctions need to be resolved to allow chromosome segregation, they are formed during homologous recombination. Both Yen1 and Mms4/Mus81 play important but not identical roles during vegetative growth and in meiosis. Yen1 and Mms4/Mus81 act as alternative resolvases for recombination events in meiosis, and the activity of at least one of them is essential to ensure proper meiosis and sporulation Saccharomyces cerevisiae