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Literature summary for 3.1.21.10 extracted from

  • Sha, R.; Liu, F.; Iwasaki, H.; Seeman, N.C.
    Parallel symmetric immobile DNA junctions as substrates for E. coli RuvC Holliday junction resolvase (2002), Biochemistry, 41, 10985-10993.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O digestion of Bowtie junctions, Holliday junctions analogue containing 5',5' and 3',3' linkages in its crossover strands. The enzyme cleaves antiparralel junctions much more efficiently than parallel junctions where the protein can bind only one site at a time. The presence of two binding sites leads to communication between the two subunits of the enzyme to increase its activity Escherichia coli hydrolyzed DNA
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Synonyms

Synonyms Comment Organism
RuvC Holliday junction resolvase
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Escherichia coli