Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the Fe(III)Zn(II) complex [(2-{[bis(2-pyridylmethyl)amino]methyl}-6-[{[2-hydroxyphenyl)methyl]-(2-pyridylmethyl)amino}methyl]-4-methylphenolFe(III)Zn(II)(micro-O2C2H3)2]ClO4 promotes thioester hydrolysis | Arabidopsis thaliana |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | thioester hydrolysis is promoted by an Fe(III)Zn(II) complex. Thioester does not initially interact with the Fe(III) center, changes occur at this site over the course of the reaction. Formation of a Fe(III)-S-methyl ester moiety, which likely results from redox activity involving an iron(III) thiolate species. Thioester hydrolysis may involve initial coordination of the deprotonated alpha-hydroxy thioester to the zinc center followed by nucleophilic attack by a terminal Fe(III)-OH moiety and thiolate leaving group stabilization by the Fe(III) center | Arabidopsis thaliana | |
Zn2+ | thioester hydrolysis is promoted by an Fe(III)Zn(II) complex. Thioester hydrolysis may involve initial coordination of the deprotonated alpha-hydroxy thioester to the zinc center followed by nucleophilic attack by a terminal Fe(III)-OH moiety and thiolate leaving group stabilization by the Fe(III) center | Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-methyl hydroxy(phenyl)ethanethioate + H2O | thioester hydrolysis is promoted by an Fe(III)Zn(II) complex | Arabidopsis thaliana | methanethiol + hydroxy(phenyl)acetic acid | - |
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Synonyms | Comment | Organism |
---|---|---|
GlxII | - |
Arabidopsis thaliana |
glyoxalase II | - |
Arabidopsis thaliana |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
saturation kinetic behavior for the phosphate diester hydrolysis reaction | Arabidopsis thaliana |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9 | saturation kinetic behavior for the thioester hydrolysis reaction. At pH 9.0 ligand exchange at the zinc center via deprotonation of the alpha-hydroxy group of the thioester to give an equilibrium amount of a zinc alkoxide species | Arabidopsis thaliana |