Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[phosphatase 2A protein]-leucine methyl ester + H2O | Mus musculus | protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways. Protein phosphatase methyl esterase (PME-1) catalyzes specifically the demethylation of the C-terminal Leu309 residue of phosphatase 2A protein catalytic subunit (PP2Ac) | [phosphatase 2A protein]-leucine + methanol | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BVQ5 | - |
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Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | embryonic | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[phosphatase 2A protein]-leucine methyl ester + H2O | protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways. Protein phosphatase methyl esterase (PME-1) catalyzes specifically the demethylation of the C-terminal Leu309 residue of phosphatase 2A protein catalytic subunit (PP2Ac) | Mus musculus | [phosphatase 2A protein]-leucine + methanol | - |
? | |
[phosphatase 2A protein]-leucine methyl ester + H2O | protein phosphatase methyl esterase (PME-1) catalyzes specifically the demethylation of the C-terminal Leu309 residue of phosphatase 2A protein catalytic subunit (PP2Ac) | Mus musculus | [phosphatase 2A protein]-leucine + methanol | - |
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Synonyms | Comment | Organism |
---|---|---|
protein phosphatase methyl-esterase PME-1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | targeted disruption of the PME-1 gene causes perinatal lethality in mice. PME-1 knockout mouse embryonic fibroblasts (MEFs) exhibit lower PP2A activity than wild type mouse embryonic fibroblasts. Loss of PME-1 enhances poly-ubiquitination of PP2Ac and shortens the half-life of PP2Ac protein resulting in reduced PP2Ac levels | Mus musculus |
physiological function | PME-1 methyl-esterase activity is necessary to maintain PP2Ac protein levels. The enzyme protects PP2Ac from ubiquitin/proteasome degradation | Mus musculus |