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Literature summary for 3.1.1.8 extracted from
- Kinetics and molecular docking studies of 6-formyl umbelliferone isolated from Angelica decursiva as an inhibitor of cholinesterase and BACE1 (2017), Molecules, 22, 1604-1616 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-amino-3-((1R)-1-cyclohexyl-2-[(cyclohexylcarbonyl)amino]ethyl)-6-phenoxyquinazolin-3-ium | - |
Equus caballus |  |
| 3,5,7,3',4'-pentamethoxyflavone | - |
Equus caballus | |
| 6-formylumbelliferone | isolated from Angelica decursiva, noncompetitive inhibition | Equus caballus | |
| 8-formylumbelliferone | noncompetitive inhibition | Equus caballus | |
| Berberine | - |
Equus caballus | |
| donepezil | - |
Equus caballus | |
| galantamine | - |
Equus caballus | |
| additional information | molecular docking, modelling, overview | Equus caballus | |
| rivastigmine | - |
Equus caballus | |
| tacrine | - |
Equus caballus | |
| umbelliferone | isolated from Angelica decursiva | Equus caballus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylcholine + H2O | Equus caballus | - |
choline + butyrate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | P81908 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Equus caballus | - |
| serum | - |
Equus caballus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| butyrylcholine + H2O | - |
Equus caballus | choline + butyrate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Equus caballus |
| butyrylcholinesterase | - |
Equus caballus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Equus caballus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Equus caballus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00981 | - |
pH 8.0, 22°C | Equus caballus | Berberine | |
| 0.0279 | - |
pH 8.0, 22°C | Equus caballus | 6-formylumbelliferone | |
| 0.08767 | - |
pH 8.0, 22°C | Equus caballus | 8-formylumbelliferone | |
| 0.09014 | - |
pH 8.0, 22°C | Equus caballus | umbelliferone | |
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