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Literature summary for 3.1.1.8 extracted from
- Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos (2018), J. Environ. Sci. Health B, 53, 191-198 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chlorpyrifos | an anticholinesterase organophosphate insecticide used in the production of food derived from animal, fruit and horticultural origin. The therapeutic treatment of castrated male bovines treated with chlorpyrifos does not cause changes in the variables evaluated, i.e. total proteins, liver enzymes, urea, and creatinine | Bos taurus |  |
| additional information | enzyme BChE is not inhibited by high concentrations of substrate | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | Bos taurus | - |
thiocholine + acetate | - |
? | |
| butyrylcholine + H2O | Bos taurus | - |
choline + butyrate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | P32749 | Aberdeen Angus beef cattle and crossbred steers, meat steers | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | - |
Bos taurus | thiocholine + acetate | - |
? | |
| butyrylcholine + H2O | - |
Bos taurus | choline + butyrate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Bos taurus |
| butyrylcholinesterase | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Bos taurus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | butyrylcholinesterase (BChE) is mainly present in plasma and generally hydrolyzes butyrylthiocholine at a higher rate than acetylthiocholine but unlike acetylcholinesterase (AChE, EC 3.1.1.7), it is not inhibited by high concentrations of substrate. In cattle, 90% of cholinesterase enzyme activity is represented by AChE in erythrocytes with very low plasma BChE values | Bos taurus |
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Release 2023.1 (January 2023)
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