Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | - |
Equus caballus | |
Cu2+ | - |
influenza C virus | |
Diethyl-4-nitrophenylphosphate | 50% inhibition at 0.0024 mM | Bos taurus | |
Diethyl-4-nitrophenylphosphate | - |
Equus caballus | |
Diethyl-4-nitrophenylphosphate | 50% inhibition at 0.24 mM | influenza C virus | |
diisopropyl fluorophosphate | 50% inhibition at 0.35 mM | Bos taurus | |
diisopropyl fluorophosphate | - |
Equus caballus | |
diisopropyl fluorophosphate | 50% inhibition at 0.01 mM | influenza C virus | |
Hg2+ | 50% inhibition at 0.0035 mM | Bos taurus | |
Hg2+ | - |
Equus caballus | |
Hg2+ | - |
influenza C virus | |
N-acetyl-9-O-acetylneuraminate | substrate inhibition above 2 mM | influenza C virus | |
physostigmine | 25% inhibition at 10 mM | Bos taurus | |
physostigmine | 25% inhibition at 10 mM | influenza C virus | |
Zn2+ | - |
Equus caballus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
4-yethylumbelliferyl acetate | - |
influenza C virus | |
0.17 | - |
4-yethylumbelliferyl acetate | - |
Bos taurus | |
0.8 | - |
N-acetyl-9-O-acetylneuraminic acid | - |
influenza C virus | |
0.9 | - |
N-acetyl-9-O-lactoylneuraminic acid | - |
influenza C virus | |
1.1 | - |
N-acetyl-9-O-acetylneuraminic acid | - |
Equus caballus | |
18 | - |
N-acetyl-9-O-acetylneuraminic acid | - |
Bos taurus | |
24 | - |
N-acetyl-9-O-lactoylneuraminic acid | - |
Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
1 * 30000 + 1 * 65000, SDS-PAGE | influenza C virus |
56500 | - |
gel filtration | Equus caballus |
56500 | - |
gel filtration and SDS-PAGE | Bos taurus |
65000 | - |
1 * 30000 + 1 * 65000, SDS-PAGE | influenza C virus |
88000 | - |
gel fitration | influenza C virus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | O-acetylated sialic acids | ? | - |
? | |
additional information | Equus caballus | O-acetylated sialic acids | ? | - |
? | |
additional information | influenza C virus | O-acetylated sialic acids | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Equus caballus | - |
- |
- |
influenza C virus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
180fold enrichment | influenza C virus |
2600fold enrichment | Bos taurus |
850fold enrichment | Equus caballus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
liver | - |
Equus caballus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxy-2,3-didehydro-N-acetyl-9-O-acetylneuraminate + H2O | 55% of the activity compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | ? | - |
? | |
2-deoxy-2,3-didehydro-N-acetyl-9-O-acetylneuraminate + H2O | 37% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | ? | - |
? | |
4-methylumbelliferyl acetate + H2O | 130% of the activity compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | 4-methylumbelliferone + acetate | - |
? | |
4-methylumbelliferyl acetate + H2O | 220% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | 4-methylumbelliferone + acetate | - |
? | |
4-methylumbelliferyl butyrate + H2O | 14% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | 4-methylumbelliferone + butyrate | - |
? | |
4-nitrophenyl acetate + H2O | 3500% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl acetate + H2O | 680% of the activity compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | 4-nitrophenol + acetate | - |
? | |
acetyl-CoA + H2O | 2% of the activity compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | CoA + acetate | - |
? | |
alpha-naphthyl acetate + H2O | 2200% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | 1-naphthol + acetate | - |
? | |
alpha-naphthyl acetate + H2O | 643% of the activity compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | 1-naphthol + acetate | - |
? | |
bovine submandibular gland mucin + H2O | 30% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | ? | - |
? | |
additional information | no hydrolysis with N-acetyl-4-O-lactoylneuraminate, N-acetyl-9-O-acetylneuraminate methyl ester | Bos taurus | ? | - |
? | |
additional information | no hydrolysis with N-acetyl-4-O-lactoylneuraminate, N-acetyl-9-O-acetylneuraminate methyl ester | influenza C virus | ? | - |
? | |
additional information | no hydrolysis with acetyl-coenzyme A, acetylthiocholine iodide | influenza C virus | ? | - |
? | |
additional information | no hydrolysis with N-glycoloyl-9-O-lactoylneuraminate, bovine submandibular gland mucin, rat serum glycoprotein, rat erythrocytes | Bos taurus | ? | - |
? | |
additional information | no hydrolysis with N-acetyl-7-O-acetylneuraminate, horse alpha1-acid glycoprotein, N-acetylneuraminate methyl ester | Bos taurus | ? | - |
? | |
additional information | no hydrolysis with N-acetyl-7-O-acetylneuraminate, horse alpha1-acid glycoprotein, N-acetylneuraminate methyl ester | Equus caballus | ? | - |
? | |
additional information | no hydrolysis with N-acetyl-7-O-acetylneuraminate, horse alpha1-acid glycoprotein, N-acetylneuraminate methyl ester | influenza C virus | ? | - |
? | |
additional information | O-acetylated sialic acids | Bos taurus | ? | - |
? | |
additional information | O-acetylated sialic acids | Equus caballus | ? | - |
? | |
additional information | O-acetylated sialic acids | influenza C virus | ? | - |
? | |
N-acetyl-4-O-acetylneuraminate + H2O | 60% of the activity compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | N-acetylneuraminate + acetate | - |
? | |
N-acetyl-4-O-acetylneuraminate + H2O | 3% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | N-acetylneuraminate + acetate | - |
? | |
N-acetyl-4-O-acetylneuraminate + H2O | no hydrolysis at pI 4.8, same rate of hydrolysis at pI 5.7 compared to N-acetyl-9-O-acetylneuraminate | Equus caballus | N-acetylneuraminate + acetate | - |
? | |
N-acetyl-9-O-acetylneuraminate + H2O | - |
Bos taurus | N-acetylneuraminate + acetate | - |
? | |
N-acetyl-9-O-acetylneuraminate + H2O | - |
influenza C virus | N-acetylneuraminate + acetate | - |
? | |
N-acetyl-9-O-acetylneuraminate + H2O | at pI 4.8 and pI 5.7 | Equus caballus | N-acetylneuraminate + acetate | - |
? | |
N-acetyl-9-O-acetylneuraminate beta-methylglycoside + H2O | 70% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | N-acetylneuraminate beta-methylglycoside + acetate | - |
? | |
N-acetyl-9-O-acetylneuraminate lactose + H2O | 96% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | N-acetylneuraminate lactose + acetate | - |
? | |
N-acetyl-9-O-acetylneuraminate lactose + H2O | same rate of hydrolysis compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | N-acetylneuraminate lactose + acetate | - |
? | |
N-acetyl-9-O-lactoylneuraminic acid + H2O | - |
Bos taurus | 9-O-lactoylneuraminic acid + acetate | - |
? | |
N-acetyl-9-O-lactoylneuraminic acid + H2O | - |
influenza C virus | 9-O-lactoylneuraminic acid + acetate | - |
? | |
rat serum glycoprotein + H2O | 90% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | ? | - |
? | |
thiophenyl acetate + H2O | 12% of the activity compared to N-acetyl-9-O-acetylneuraminate | influenza C virus | thiophenol + acetate | - |
? | |
thiophenyl acetate + H2O | 305% of the activity compared to N-acetyl-9-O-acetylneuraminate | Bos taurus | thiophenol + acetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 30000 + 1 * 65000, SDS-PAGE | influenza C virus |
monomer | 1* 56500, gel filtration and SDS-PAGE | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Bos taurus |
7.8 | - |
- |
influenza C virus |
8.5 | - |
- |
Equus caballus |