Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | isoform Lse, secreted from post-Golgi vesicle, limited lysosomal localisation | Mus musculus | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | enhanced B-cell receptor signalling through hyper-9-O-acetylation of alpha2-6-linked sialic acid on N-glycans and defective CD22 inhibitory signalling in absence of the enzyme | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
C57BL/6 wild-type or homozygous Siae deficient knockout mice, and B6.129S7-Rag1-deficient mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | catalytic regulation of B cell receptor (BCR) signalling and B-cell development, knockout mice: striking decrease in number of splenic marginal zone B-cells and marginal zone B-cell precursors, reduced number in follicular B-cells, loss of recirculating B-cells in bone marrow, lymphocyte-intrinsic defects | Mus musculus | - |
splenocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enhanced B-cell receptor signalling through hyper-9-O-acetylation of alpha2-6-linked sialic acid on N-glycans and defective CD22 inhibitory signalling in absence of the enzyme | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
9-O-acetyl sialic acid esterase | Siae gene encodes two splice forms | Mus musculus |
Lse | one splice variant | Mus musculus |
SIAE | - |
Mus musculus |
sialate-O-acetylesterase | - |
Mus musculus |
sialate: O-acetyl esterase | - |
Mus musculus |
sialic acid acetyl esterase | - |
Mus musculus |
sialic acid O-acetylesterase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | mice with a mutation in sialate: O-acetyl esterase (inframe deletion of exon 2, resulting in a protein lacking esterase activity) exhibit enhanced B cell receptor activation, defects in peripheral B cell development, and spontaneously develop antichromatin autoantibodies and glomerular immune complex deposits. The 9-O-acetylation state of sialic acid regulates the function of CD22, a Siglec that functions in vivo as an inhibitor of BCR signaling | Mus musculus |