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Literature summary for 3.1.1.47 extracted from
- Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2) (2009), Cardiovasc. Drugs Ther., 23, 73-83.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A379V | nonsynonymous polymorphism | Homo sapiens |
| I198T | nonsynonymous polymorphism | Homo sapiens |
| I317N | inactivating mutation | Homo sapiens |
| Q281R | inactivating mutation | Homo sapiens |
| R92H | nonsynonymous polymorphism | Homo sapiens |
| V279F | inactivating mutation | Homo sapiens |
| V379F | nonsynonymous polymorphism | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | - |
1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |  |
| platelet-activating factor + H2O | Homo sapiens | - |
lyso-platelet-activating factor + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| secretion | secreted protein that circulates in plasma in activated form | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
| additional information | catalyzes the removal of the acyl group at the sn-2 position of platelet-activating factor and truncated phospholipids | Homo sapiens | ? | - |
? | |
| platelet-activating factor + H2O | - |
Homo sapiens | lyso-platelet-activating factor + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipoprotein associated phospholipase A2 | - |
Homo sapiens |
| PAF-acetylhydrolase | - |
Homo sapiens |
| PAF-AH | - |
Homo sapiens |
| PLA2G7 | - |
Homo sapiens |
| platelet-activating factor acetylhydrolase | - |
Homo sapiens |
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