Cloned (Comment) | Organism |
---|---|
expression in COS-7 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
N273 | mutation in potential N-glycosylation site, reduction in catalytic activity, mutant is recovered in the soluble fraction | Homo sapiens |
N289 | mutation in potential N-glycosylation site, reduction in catalytic activity, mutant is recovered in the soluble fraction | Homo sapiens |
N398 | mutation in potential N-glycosylation site, reduction in catalytic activity, mutant is recovered in the soluble fraction | Homo sapiens |
N99 | mutation in potential N-glycosylation site, marked reduction in catalytic activity, mutant is mostly retained in the membrane fraction | Homo sapiens |
N99/N273/N289/N398 | mutation in all potential glycosylation sites, loss of catalyic activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NCC3 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | isoform LPLA2 contains four potential N-glycosylation sites. Single mutation at potential glycosylation sites N273, N289, or N398 partially reduces production of active enzyme. Single mutation at N99 and quadruple mutations at all four Asn sites results in a marked reduction of active LPLA2 and loss of active LPLA2, respectively | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Lpla2 | - |
Homo sapiens |
lysosomal phospholipase A2 | - |
Homo sapiens |