Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphate | phosphorylation needed for activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | - |
Homo sapiens | |
EDTA | - |
Homo sapiens | |
EGTA | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+-dependent PLA2-association with cellular membranes at a concentration of 300-500 nM | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
78000 | - |
native PAGE | Homo sapiens |
100000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipids + H2O | Homo sapiens | eicosanoids | ? | - |
? | |
phospholipids + H2O | Homo sapiens | inflammatory diseases | ? | - |
? | |
phospholipids + H2O | Homo sapiens | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
column chromatography, gel electrophoresis, 1206fold | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | peripheral blood | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0609 | - |
substrate: 1-palmitoyl-2-arachidonylphosphatidylcholine | Homo sapiens |
Storage Stability | Organism |
---|---|
-70°C, with bovine serum albumin, loss of enzyme activity only partially avoided | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acyl-2-arachidonoyl-sn-glycerophosphoethanolamine + H2O | - |
Homo sapiens | 1-acyl-sn-glycerophosphoethanolamine + arachidonic acid | - |
? | |
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylcholine + arachidonic acid | - |
? | |
phosphatidylcholine + arachidonic acid | - |
Homo sapiens | 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine + carboxylic acid | - |
r | |
phosphatidylcholine + H2O | - |
Homo sapiens | 1-acylglycerophosphocholine + fatty acid | - |
? | |
phosphatidylcholine + linoleic acid | - |
Homo sapiens | lineoyl phosphatidylcholine | - |
? | |
phosphatidylethanolamine + arachidonic acid | - |
Homo sapiens | arachidonoyl phosphatidylethanolamine | - |
r | |
phosphatidylethanolamine + linoleic acid | - |
Homo sapiens | lineoyl phosphatidylethanolamine + fatty acid | - |
? | |
phosphatidylinositol + arachidonic acid | - |
Homo sapiens | arachidonoyl phosphatidylinositol + fatty acid | - |
? | |
phosphatidylinositol + linoleic acid | - |
Homo sapiens | lineoyl phosphatidylinositol + fatty acid | - |
? | |
phosphatidylserine + arachidonic acid | - |
Homo sapiens | arachidonoyl phosphatidylserine + fatty acid | - |
? | |
phosphatidylserine + linoleic acid | - |
Homo sapiens | lineoyl phosphatidylserine + fatty acid | - |
? | |
phospholipids + H2O | eicosanoids | Homo sapiens | ? | - |
? | |
phospholipids + H2O | inflammatory diseases | Homo sapiens | ? | - |
? | |
phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Homo sapiens |