Any feedback?
Literature summary for 3.1.1.13 extracted from
- Site-directed mutagenesis of the distal basic cluster of pancreatic bile salt-dependent lipase (2004), J. Biol. Chem., 279, 39697-39704.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K423A/K429I/R454A/R458A/K462I | in absence of bile salt, activity comparable to wild-type. Activation by taurocholate is about 50% of wild-type activation, activation occurs only at bile salt concentration in the range of their respective critical micellar concentration | Rattus norvegicus |
| Y427S | activity on soluble substrate similar to wild-type, activity on cholesteryl oleate solubilized in primary bile salt micelles is decreased | Rattus norvegicus |
| Y453S | activity on soluble substrate similar to wild-type, activity on cholesteryl oleate solubilized in primary bile salt micelles is decreased | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BSDL | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
