KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00034 | - |
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin | isozyme CE-2 | Homo sapiens | |
0.0043 | - |
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin | isozyme CE-1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O | Homo sapiens | isozyme CE-2 is responsible for activation of the prodrug | 7-ethyl-10-hydroxy-camptothecin + ? | i.e. SN-38 | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes CE-1 and CE-2 | - |
Purification (Comment) | Organism |
---|---|
isozymes CE-1 and CE-2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | isozymes CE-1 and CE-2 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
isozyme CE-2 shows 5fold higher activity with substrate 7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin than isozyme CE-1 | Homo sapiens |
40 | 140 | isozyme CE-2 | Homo sapiens |
610 | - |
isozyme CE-1 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl acetate + H2O | - |
Homo sapiens | 4-methylumbelliferol + acetate | - |
? | |
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O | activation of the prodrug, i.e. CPT-11 or irinotecan, a commercial topoisomerase I inhibitor commonly used for treatment of colorectal tumors | Homo sapiens | 7-ethyl-10-hydroxy-camptothecin + ? | i.e. SN-38 | ? | |
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O | isozyme CE-2 is responsible for activation of the prodrug | Homo sapiens | 7-ethyl-10-hydroxy-camptothecin + ? | i.e. SN-38 | ? |
Synonyms | Comment | Organism |
---|---|---|
CE | - |
Homo sapiens |