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Literature summary for 2.9.1.2 extracted from

  • Yuan, J.; Palioura, S.; Salazar, J.C.; Su, D.; O'Donoghue, P.; Hohn, M.J.; Cardoso, A.M.; Whitman, W.B.; Söll, D.
    RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea (2006), Proc. Natl. Acad. Sci. USA, 103, 18923-18927.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.9.1.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
-
 Methanococcus maripaludis
-
 Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-phospho-L-seryl-tRNASec + selenophosphate Methanococcus maripaludis L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) L-selenocysteinyl-tRNASec + phosphate
-
 ?
O-phospho-L-seryl-tRNASec + selenophosphate Methanocaldococcus jannaschii L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) L-selenocysteinyl-tRNASec + phosphate
-
 ?
O-phospho-L-seryl-tRNASec + selenophosphate Homo sapiens L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase L-selenocysteinyl-tRNASec + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HD40
-
-
Methanocaldococcus jannaschii Q58027
-
-
Methanococcus maripaludis Q6LZM9
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens
recombinant enzyme Methanococcus maripaludis
recombinant enzyme Methanocaldococcus jannaschii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-phospho-L-seryl-tRNASec + selenophosphate
-
 Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
 ?
O-phospho-L-seryl-tRNASec + selenophosphate
-
 Methanococcus maripaludis L-selenocysteinyl-tRNASec + phosphate
-
 ?
O-phospho-L-seryl-tRNASec + selenophosphate
-
 Methanocaldococcus jannaschii L-selenocysteinyl-tRNASec + phosphate
-
 ?
O-phospho-L-seryl-tRNASec + selenophosphate L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanococcus maripaludis L-selenocysteinyl-tRNASec + phosphate
-
 ?
O-phospho-L-seryl-tRNASec + selenophosphate L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii L-selenocysteinyl-tRNASec + phosphate
-
 ?
O-phospho-L-seryl-tRNASec + selenophosphate L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
SepSecS
-
 Homo sapiens
SepSecS
-
 Methanococcus maripaludis
SepSecS
-
 Methanocaldococcus jannaschii
SLA/LP
-
 Homo sapiens
SLA/LP
-
 Methanococcus maripaludis
SLA/LP
-
 Methanocaldococcus jannaschii

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine Homo sapiens
pyridoxal 5'-phosphate the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine Methanococcus maripaludis
pyridoxal 5'-phosphate the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine Methanocaldococcus jannaschii