Activating Compound | Comment | Organism | Structure |
---|---|---|---|
6-methylene-4-pregnene-3,20-dione | activates the hepatic enzyme in sham-operated and castrated male rats, effect is counteracted by 5alpha-dihydrotestosterone | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5alpha-dihydrotestosterone | inhibits the hepatic enzyme in sham-operated and castrated male rats, prevents activation by 6-methylene-4-pregnene-3,20-dione | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000012 | - |
castrated male rats with 5alpha-dihydrotestosterone, hepatic enzyme | Rattus norvegicus |
0.000017 | - |
sham-operated male rats with 5alpha-dihydrotestosterone, hepatic enzyme | Rattus norvegicus |
0.000019 | - |
sham-operated male rats with 5alpha-dihydrotestosterone and 6-methylene-4-pregnene-3,20-dione, hepatic enzyme | Rattus norvegicus |
0.000023 | - |
sham-operated male rats, hepatic enzyme | Rattus norvegicus |
0.000056 | - |
sham-operated male rats with 6-methylene-4-pregnene-3,20-dione, hepatic enzyme | Rattus norvegicus |
0.00006 | - |
castrated male rats, hepatic enzyme | Rattus norvegicus |
0.000083 | - |
castrated male rats with 6-methylene-4-pregnene-3,20-dione, hepatic enzyme | Rattus norvegicus |