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Literature summary for 2.8.2.30 extracted from

  • Sikora, A.S.; Delos, M.; Martinez, P.; Carpentier, M.; Allain, F.; Denys, A.
    Regulation of the expression of heparan sulfate 3-O-sulfotransferase 3B (HS3ST3B) by inflammatory stimuli in human monocytes (2016), J. Cell. Biochem., 117, 1529-1542.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
heparan sulfate 3-O-sulfotransferase 3B
-
 Homo sapiens
HS3ST3B
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of isoform HS3ST3B is markedly up-regulated in human primary monocytes and the related cell line THP-1 after exposure to toll-like receptor agonists. tumor necrosis factor-alpha is also efficient, to a lesser extent, to increase isoform HS3ST3B expression, while interleukin-6, interleukin-4, and interferon-gamma are poor inducers. Lipopolysaccharide induces a rapid and strong transcription of the HS3ST3B1 gene up