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Literature summary for 2.8.2.30 extracted from

  • Moon, A.F.; Xu, Y.; Woody, S.M.; Krahn, J.M.; Linhardt, R.J.; Liu, J.; Pedersen, L.C.
    Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin (2012), Proc. Natl. Acad. Sci. USA, 109, 5265-5270.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.30

Protein Variants

Protein Variants Comment Organism
K259A the mutant shows 13.1% activity compared to the wild type enzyme Mus musculus
T256A the mutant shows 101.5% activity compared to the wild type enzyme Mus musculus
T256E the mutant shows 13.1% activity compared to the wild type enzyme Mus musculus
T256V the mutant shows 59.4% activity compared to the wild type enzyme Mus musculus
W283A the mutant shows 7.6% activity compared to the wild type enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Mus musculus
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Mus musculus adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
3-OST-3
-
 Mus musculus
heparan sulfate 3-O-sulfotransferase 3
-
 Mus musculus