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Literature summary for 2.7.9.1 extracted from

  • Minges, A.; Groth, G.
    Small-molecule inhibition of pyruvate phosphate dikinase targeting the nucleotide binding site (2017), PLoS ONE, 12, e0181139 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.9.1

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression in Escherichia coli strain BL21 (DE3) Flaveria pringlei

Inhibitors

Inhibitors Comment Organism Structure
2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide i.e. Go 6983 Flaveria pringlei
2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
-
 Flaveria pringlei
2-hydroxy-5-methoxy-3-[[(1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylenedecahydro-1-naphthalenyl]methyl]-1,4-benzoquinone
-
 Flaveria pringlei
6-bromoindirubin-3'-monoxime
-
 Flaveria pringlei
bisindolylmaleimide
-
 Flaveria pringlei
indirubin-3'-monoxime
-
 Flaveria pringlei
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
-
 Flaveria pringlei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate + phosphate Flaveria pringlei
-
 AMP + phosphoenolpyruvate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Flaveria pringlei Q42736
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Flaveria pringlei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate + phosphate
-
 Flaveria pringlei AMP + phosphoenolpyruvate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PPDK
-
 Flaveria pringlei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
-
 42 pH 8.0, 30°C Flaveria pringlei indirubin-3'-monoxime
0.00076
-
 pH 8.0, 30°C Flaveria pringlei bisindolylmaleimide
0.0015
-
 pH 8.0, 30°C Flaveria pringlei 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide
0.0112
-
 pH 8.0, 30°C Flaveria pringlei N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
0.0162
-
 pH 8.0, 30°C Flaveria pringlei 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
0.113
-
 pH 8.0, 30°C Flaveria pringlei 6-bromoindirubin-3'-monoxime
0.74
-
 pH 8.0, 30°C Flaveria pringlei 2-hydroxy-5-methoxy-3-[[(1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylenedecahydro-1-naphthalenyl]methyl]-1,4-benzoquinone

General Information

General Information Comment Organism
physiological function essential enzyme of C4 photosynthesis in plants Flaveria pringlei