BRENDA - Enzyme Database
show all sequences of 2.7.8.27

Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme

Luberto, C.; Stonehouse, M.J.; Collins, E.A.; Marchesini, N.; El-Bawab, S.; Vasil, A.I.; Vasil, M.L.; Hannun, Y.A.; J. Biol. Chem. 278, 32733-32743 (2003)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Mn2+
4 mM, about 40% inhibition
Pseudomonas aeruginosa
Ni2+
2 mM, 75% inhibition
Pseudomonas aeruginosa
tricyclodecan-9-yl-xanthogenate
i.e. D609
Pseudomonas aeruginosa
Zn2+
0.5 mM, about 95% inhibition
Pseudomonas aeruginosa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas aeruginosa
-
strain PA01 and PAK
-
Purification (Commentary)
Commentary
Organism
-
Pseudomonas aeruginosa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
culture medium
-
Pseudomonas aeruginosa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
highly purified sphingomyelin synthase preparation also shows neutral sphingomyelinase activity
669200
Pseudomonas aeruginosa
?
-
-
-
-
phosphatidylcholine + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine
-
669200
Pseudomonas aeruginosa
N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
-
-
ir
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.5
-
Pseudomonas aeruginosa
pH Range
pH Minimum
pH Maximum
Commentary
Organism
7
9.5
pH 7: about 50% of maximal activity, pH 9.5: 65% of maximal activity
Pseudomonas aeruginosa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Mn2+
4 mM, about 40% inhibition
Pseudomonas aeruginosa
Ni2+
2 mM, 75% inhibition
Pseudomonas aeruginosa
tricyclodecan-9-yl-xanthogenate
i.e. D609
Pseudomonas aeruginosa
Zn2+
0.5 mM, about 95% inhibition
Pseudomonas aeruginosa
Purification (Commentary) (protein specific)
Commentary
Organism
-
Pseudomonas aeruginosa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
culture medium
-
Pseudomonas aeruginosa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
highly purified sphingomyelin synthase preparation also shows neutral sphingomyelinase activity
669200
Pseudomonas aeruginosa
?
-
-
-
-
phosphatidylcholine + 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine
-
669200
Pseudomonas aeruginosa
N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
-
-
ir
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.5
-
Pseudomonas aeruginosa
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
7
9.5
pH 7: about 50% of maximal activity, pH 9.5: 65% of maximal activity
Pseudomonas aeruginosa
Other publictions for EC 2.7.8.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737776
Sugimoto
Characterization of the role o ...
Mus musculus, Mus musculus C57BL/6N
Biochim. Biophys. Acta
1861
688-702
2016
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1
1
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1
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2
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2
2
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739087
Hu
Sphingomyelin synthase 2 affec ...
Mus musculus
Mol. Med. Rep.
14
3301-3306
2016
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1
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5
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1
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1
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1
1
1
1
-
-
737844
Li
Discovery, synthesis and biolo ...
Homo sapiens
Bioorg. Med. Chem.
23
6173-6184
2015
-
1
1
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26
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1
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1
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1
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2
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2
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1
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1
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25
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1
1
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25
26
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1
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1
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2
-
-
2
-
1
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-
-
1
-
-
-
-
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-
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737747
Piotto
Differential effect of 2-hydro ...
Homo sapiens
Biochim. Biophys. Acta
1838
1628-1637
2014
1
-
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738955
Huang
Analysis of fluorescent cerami ...
Mus musculus
Lipids
49
1071-1079
2014
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1
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2
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1
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1
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2
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1
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2
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1
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2
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3
-
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-
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1
1
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721280
Chen
Development of a quantitative ...
Homo sapiens
Anal. Biochem.
438
61-66
2013
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1
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1
4
1
-
1
2
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3
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6
1
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2
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2
2
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2
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2
2
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6
2
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722907
Burns
Sphingomyelin synthase 1 activ ...
Homo sapiens
J. Lipid Res.
54
794-805
2013
-
-
-
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1
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3
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-
1
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2
1
1
2
-
-
738307
Hu
-
Construction and identificatio ...
Homo sapiens
Fudan Univ. J. Med. Sci.
40
584-588
2013
-
-
-
-
1
-
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2
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1
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2
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2
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738936
Thomaseth
Modeling sphingomyelin synthas ...
Homo sapiens
J. Theor. Biol.
337
174-180
2013
-
-
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3
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1
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1
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1
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3
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1
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1
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1
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-
2
2
-
-
-
739480
Hsiao
Elevation in sphingomyelin syn ...
Homo sapiens
PLoS ONE
8
e74016
2013
-
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1
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1
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3
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3
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2
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2
2
-
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-
721500
Kidani
Differential localization of s ...
Mus musculus
Biochem. Biophys. Res. Commun.
417
1014-1017
2012
-
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2
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1
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3
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-
1
1
-
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-
723081
Zhao
Sphingomyelin synthase 2 over- ...
Homo sapiens
Life Sci.
90
867-873
2012
-
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1
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2
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1
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1
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1
1
-
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-
723175
Asano
Regulation of cell migration b ...
Mus musculus
Mol. Cell. Biol.
32
3242-3252
2012
-
-
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2
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1
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1
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1
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2
2
-
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-
723168
Man
Molecular cloning, sequence ch ...
Gallus gallus
Mol. Cell. Biochem.
357
353-361
2011
-
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1
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-
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1
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1
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5
-
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12
-
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1
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1
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1
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1
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12
-
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-
1
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-
-
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723307
Yeang
Subcellular targeting domains ...
Homo sapiens, Mus musculus
Nutr. Metab.
8
89
2011
-
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2
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3
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2
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2
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723537
Subathra
Sphingomyelin synthases regula ...
Homo sapiens, Rattus norvegicus
PLoS ONE
6
e23644
2011
-
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2
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4
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2
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1
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1
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2
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4
4
-
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-
723643
Barcelo-Coblijn
Sphingomyelin and sphingomyeli ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
108
19569-19574
2011
1
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723525
Qureshi
Role of sphingomyelin synthase ...
Homo sapiens
PLoS ONE
5
e15587
2010
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2
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707306
Liu
Sphingomyelin synthase 2 is on ...
Mus musculus
Arterioscler. Thromb. Vasc. Biol.
29
850-856
2009
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707360
Tani
Sphingomyelin synthase 2 is pa ...
Homo sapiens
Biochem. Biophys. Res. Commun.
381
328-332
2009
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1
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1
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708149
Liu
Macrophage sphingomyelin synth ...
Mus musculus
Circ. Res.
105
295-303
2009
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1
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1
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3
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1
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1
1
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709216
Vacaru
Sphingomyelin synthase-related ...
Homo sapiens
J. Cell Biol.
185
1013-1027
2009
-
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1
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1
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1
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1
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709422
Ternes
Sphingomyelin synthase SMS2 di ...
Homo sapiens
J. Lipid Res.
50
2270-2277
2009
-
-
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2
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690656
Hailemariam
Sphingomyelin synthase 2 defic ...
Homo sapiens, Mus musculus
Arterioscler. Thromb. Vasc. Biol.
28
1519-1526
2008
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2
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2
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2
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3
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2
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Identification of a family of ...
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Sphingomyelin synthase as a po ...
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Enzyme distributions in subcel ...
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Sphingomyelin synthase in rat ...
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Microsomal sphingomyelin accum ...
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Functional reconstitution of s ...
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