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Literature summary for 2.7.8.2 extracted from
- Stimulation of platelet-activating factor synthesis in human endothelial cells by activation of the de novo pathway. Phorbol 12-myristate 13-acetate activates 1-alkyl-2-lyso-sn-glycero-3-phosphate:acetyl-CoA acetyltransferase and dithiothreitol-insensitive 1-alkyl-2-acetyl-sn-glycerol:CDP-choline cholinephosphotransferase (1991), J. Biol. Chem., 266, 21358-21361.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | dithiothreitol-insensitive enzyme | Homo sapiens |  |
| phorbol 12-myristate 13-acetate | activates | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | dithiothreitol-insensitive activity | ? | - |
? | |
| additional information | Homo sapiens | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| umbilical vein endothelium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-choline + 1,2-diacylglycerol | - |
Homo sapiens | CMP + a phosphatidylcholine | - |
? | |
| additional information | dithiothreitol-insensitive activity | Homo sapiens | ? | - |
? | |
| additional information | final step of the biosynthesis of platelet activating factor, PAF, in the de novo pathway | Homo sapiens | ? | - |
? | |
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