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Literature summary for 2.7.7.88 extracted from

  • Ogino, M.; Ogino, T.
    5'-Phospho-RNA acceptor specificity of GDP polyribonucleotidyltransferase of vesicular stomatitis virus in mRNA capping (2017), J. Virol., 91, e02322-16 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.88

Inhibitors

Inhibitors Comment Organism Structure
2',3'-dideoxyguanosine 5'-diphosphate
-
 vesicular stomatitis virus
2'-deoxyguanosine 5'-diphosphate
-
 vesicular stomatitis virus
2,6-diaminopurine-riboside 5'-diphosphate
-
 vesicular stomatitis virus
2-aminopurine-riboside 5'-diphosphate
-
 vesicular stomatitis virus
3'-deoxyguanosine 5'-diphosphate
-
 vesicular stomatitis virus
7-deazaguanosine 5'-diphosphate
-
 vesicular stomatitis virus
7-methylguanosine 5'-diphosphate
-
 vesicular stomatitis virus
ADP
-
 vesicular stomatitis virus
IDP
-
 vesicular stomatitis virus
ribavirin 5'-diphosphate
-
 vesicular stomatitis virus
XDP
-
 vesicular stomatitis virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00003
-
 GDP at pH 7.5 and 30°C vesicular stomatitis virus
0.0004
-
 5'-triphospho-AACAG at pH 7.5 and 30°C vesicular stomatitis virus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-triphospho-mRNA + GDP vesicular stomatitis virus
-
 diphosphate + guanosine 5'-triphospho-mRNA
-
 ?

Organism

Organism UniProt Comment Textmining
vesicular stomatitis virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-triphospho-AACAG + 2,6-diaminopurine-riboside 5'-diphosphate
-
 vesicular stomatitis virus diphosphate + 2,6-diaminopurine-riboside 5'-triphospho-AACAG
-
 ?
5'-triphospho-AACAG + 7-deazaguanosine 5'-diphosphate
-
 vesicular stomatitis virus diphosphate + 7-deazaguanosine 5'-triphospho-AACAG
-
 ?
5'-triphospho-AACAG + 7-methylguanosine 5'-diphosphate
-
 vesicular stomatitis virus diphosphate + 7-methylguanosine 5'-triphospho-AACAG
-
 ?
5'-triphospho-AACAG + GDP
-
 vesicular stomatitis virus diphosphate + guanosine 5'-triphospho-AACAG
-
 ?
5'-triphospho-mRNA + GDP
-
 vesicular stomatitis virus diphosphate + guanosine 5'-triphospho-mRNA
-
 ?

Synonyms

Synonyms Comment Organism
GDP polyribonucleotidyltransferase
-
 vesicular stomatitis virus
L protein
-
 vesicular stomatitis virus
PRNTase
-
 vesicular stomatitis virus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000036
-
 2,6-diaminopurine-riboside 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.000038
-
 7-methylguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.00004
-
 7-deazaguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.000053
-
 2'-deoxyguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.000058
-
 3'-deoxyguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.00014
-
 2-aminopurine-riboside 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.00038
-
 2',3'-dideoxyguanosine 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.0007
-
 IDP at pH 7.5 and 30°C vesicular stomatitis virus
0.00095
-
 ribavirin 5'-diphosphate at pH 7.5 and 30°C vesicular stomatitis virus
0.0026
-
 ADP at pH 7.5 and 30°C vesicular stomatitis virus
0.0064
-
 XDP at pH 7.5 and 30°C vesicular stomatitis virus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00037
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2,6-diaminopurine-riboside 5'-diphosphate
0.00039
-
 at pH 7.5 and 30°C vesicular stomatitis virus 7-methylguanosine 5'-diphosphate
0.0004
-
 at pH 7.5 and 30°C vesicular stomatitis virus 7-deazaguanosine 5'-diphosphate
0.00053
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2'-deoxyguanosine 5'-diphosphate
0.00057
-
 at pH 7.5 and 30°C vesicular stomatitis virus 3'-deoxyguanosine 5'-diphosphate
0.0013
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2-aminopurine-riboside 5'-diphosphate
0.0035
-
 at pH 7.5 and 30°C vesicular stomatitis virus 2',3'-dideoxyguanosine 5'-diphosphate
0.0064
-
 at pH 7.5 and 30°C vesicular stomatitis virus IDP
0.0086
-
 at pH 7.5 and 30°C vesicular stomatitis virus ribavirin 5'-diphosphate
0.023
-
 at pH 7.5 and 30°C vesicular stomatitis virus ADP
0.058
-
 at pH 7.5 and 30°C vesicular stomatitis virus XDP