Organism | UniProt | Comment | Textmining |
---|---|---|---|
Listeria monocytogenes | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
dacA | - |
Listeria monocytogenes |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Listeria monocytogenes |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Listeria monocytogenes |
General Information | Comment | Organism |
---|---|---|
malfunction | reduction of cyclic di-3',5'-adenylate levels by conditional depletion of the di-adenylate cyclase DacA leads to marked decreases in growth rates, both in vitro and in macrophages. Conditional depletion of dacA also leads to increased IFN-beta expression and a concomitant increase in host cell pyroptosis, a result of increased bacteriolysis and subsequent bacterial DNA release | Listeria monocytogenes |
physiological function | cyclic di-3',5'-adenylate coordinates bacterial growth, cell wall stability, and responses to stress and plays a crucial role in the establishment of bacterial infection | Listeria monocytogenes |