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Literature summary for 2.7.7.7 extracted from

  • Ghosh, S.; Goldgur, Y.; Shuman, S.
    Mycobacterial DNA polymerase I activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme (2020), Nucleic Acids Res., 48, 3165-3180 .
    View publication on PubMed
Search for more literature for 2.7.7.7

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion, crystal structures of the POL domain, as apoenzyme and as ternary complex with 3'-dideoxy-terminated DNA primer-template and dNTP Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Mycolicibacterium smegmatis
-
 diphosphate + DNAn+1
-
 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Mycolicibacterium smegmatis ATCC 700084
-
 diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0QYZ2
-
-
Mycolicibacterium smegmatis ATCC 700084 A0QYZ2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
-
 Mycolicibacterium smegmatis diphosphate + DNAn+1
-
 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Pol1 has flap endonuclease activity on the flap RNA strand of an RNA:DNA hybrid duplex as well as reverse transcriptase activity on a DNA-primed RNA template Mycolicibacterium smegmatis diphosphate + DNAn+1
-
 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
-
 Mycolicibacterium smegmatis ATCC 700084 diphosphate + DNAn+1
-
 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Pol1 has flap endonuclease activity on the flap RNA strand of an RNA:DNA hybrid duplex as well as reverse transcriptase activity on a DNA-primed RNA template Mycolicibacterium smegmatis ATCC 700084 diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
POL1
-
 Mycolicibacterium smegmatis