Cloned (Comment) | Organism |
---|---|
a fusion protein consisting of bacterial maltose-binding protein and full-length HSV 1 POL is constructed with either one factor Xa cleavage site at the linker region or with a second factor Xa site right after Asn-42 of HSV POL. The maltose-binding protein-HSV POL fusion protein is expressed in a baculovirus/insect cell system | Human alphaherpesvirus 1 |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion, crystal structure at 2.7 A resolution, crystals of HSV POL belong to space group P212121, with typical unit cell dimensions of a = 103.9 A, b = 125.6 A, c = 220.6 A | Human alphaherpesvirus 1 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-oxo-dihydroquinoline | binds at the polymerase active site interacting non-covalently with both the polymerase and the DNA duplex | Human alphaherpesvirus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human alphaherpesvirus 1 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
HSV 1 POL | - |
Human alphaherpesvirus 1 |