Literature summary for 2.7.7.65 extracted from

Muriel, C.; Blanco-Romero, E.; Trampari, E.; Arrebola, E.; Duran, D.; Redondo-Nieto, M.; Malone, J.G.; Martin, M.; Rivilla, R.
The diguanylate cyclase AdrA regulates flagellar biosynthesis in Pseudomonas fluorescens F113 through SadB (2019), Sci. Rep., 9, 8096 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene adrA, recombinant overexpression in Pseudomonas fluorescens strain F113 and in Escherichia coli strain DH5alpha	Pseudomonas fluorescens

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of the adrA mutant harbouring the pCdrA::gfpC biosensor vector, the adrA mutant shows enhanced fliC expression	Pseudomonas fluorescens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	AdrA is a predicted membrane protein with a putative sensory domain	Pseudomonas fluorescens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas fluorescens	-	-	-
Pseudomonas fluorescens F113	-	-	-

Synonyms

Synonyms	Comment	Organism
AdrA	-	Pseudomonas fluorescens

General Information

General Information	Comment	Organism
metabolism	AdrA acts independently of the Gac system, which is also consistent with the activity of AdrA in the SadB branch of the signaling pathway, hypothetical regulatory model for flagellar synthesis in Pseudomonas fluorescens strain F113, overview	Pseudomonas fluorescens
physiological function	the diguanylate cyclase AdrA regulates flagellar biosynthesis in Pseudomonas fluorescens F113 through SadB. AdrA is a diguanylate cyclase implicated in c-di-GMP-mediated cellulose production and biofilm formation. AdrA is involved in swimming and biofilm formation, since inactivation of the adrA gene results in increased swimming motility and a reduction in the initial stages of attachment to surfaces. The enzyme is implicated in flagellar gene expression, genetic interaction between adrA and sadB indicates that AdrA participates in the regulation of flagella biogenesis	Pseudomonas fluorescens

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Release 2023.1 (January 2023)