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Literature summary for 2.7.7.6 extracted from

  • Raindlova, V.; Janouskova, M.; Slavickova, M.; Perlikova, P.; Bohacova, S.; Milisavljevic, N.; Sanderova, H.; Benda, M.; Barvik, I.; Krasny, L.; Hocek, M.
    Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases (2016), Nucleic Acids Res., 44, 3000-3012 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Bacillus subtilis
-
 diphosphate + RNAn+1
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 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Bacillus subtilis diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn DNA templates containing smaller base modifications in 2'-deoxyribonucleoside triphosphates (H, Me in 7-deazapurines) are perfectly tolerated whereas bulky modifications (Ph at any nucleobase) and uracil blocked transcription. Some middle-sized modifications (vinyl or ethynyl) are partly tolerated. In all cases where the transcription proceeds, full length RNA product with correct sequence is obtained indicating that the modifications of the template are not mutagenic and the inhibition is probably at the stage of initiation Bacillus subtilis diphosphate + RNAn+1
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 ?

Synonyms

Synonyms Comment Organism
RNAP
-
 Bacillus subtilis