Organism | UniProt | Comment | Textmining |
---|---|---|---|
Vaccinia virus | P04298 | mRNA-capping enzyme catalytic subunit | - |
Vaccinia virus IHDW | P04298 | mRNA-capping enzyme catalytic subunit | - |
General Information | Comment | Organism |
---|---|---|
physiological function | in Dts36, a temperature sensitive virus mutant affecting the large subunit of the capping enzyme, of the three enzymatic activities required for mRNA capping, the guanylyltransferase and methyltransferase activities are compromised while the triphosphatase activity and the D12 subunit interaction are unaffected. The mutant enzyme is also defective in stimulating early gene transcription termination and intermediate gene transcription initiation in vitro | Vaccinia virus |