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Literature summary for 2.7.7.19 extracted from

  • Mansur, F.; Alarcon, J.; Stackpole, E.; Wang, R.; Richter, J.
    Noncanonical cytoplasmic poly(A) polymerases regulate RNA levels, alternative RNA processing, and synaptic plasticity but not hippocampal-dependent behaviours (2020), RNA Biol., 18, 962-971 .
    View publication on PubMed
Search for more literature for 2.7.7.19

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNAn Mus musculus
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q68ED3
-
-
Mus musculus Q91YI6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNAn
-
 Mus musculus diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
GLD2 isoform, also called TENT2, TUTase2, TUT2 or PAPD4 Mus musculus
GLD4 isoform, also called TENT4B, PAPD5, TUTase3, TUT3 Mus musculus
poly(A) polymerase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction double isoform Gld2/Gld4 depletion results in a strong deficit in theta burst stimulation-long term potentiation and an enhancement of N-methyl-D-aspartate receptor-dependent long term depression. Gld4 depletion has negligible effects on hippocampal-dependent behaviors Mus musculus
malfunction isoform Gld2 depletion from the mouse hippocampus results in a deficit in long term potentiation. Double isoform Gld2/Gld4 depletion results in a strong deficit in theta burst stimulation-long term potentiation and an enhancement of N-methyl-D-aspartate receptor-dependent long term depression. Gld2 depletion has negligible effects on hippocampal-dependent behaviors Mus musculus
physiological function isoform Gld2 is essential for normal synaptic efficacy at least in the dentate gyrus of the hippocampus. Isoform Gld2 controls RNA processing, particularly exon skipping Mus musculus
physiological function isoform Gld4 controls RNA processing, particularly exon skipping Mus musculus