Literature summary for 2.7.7.18 extracted from

Pottorf, T.; Mann, A.; Fross, S.; Mansel, C.; Vohra, B.P.S.
Nicotinamide mononucleotide adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of golgi structure (2018), Neurochem. Int., 121, 86-97 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BNJ3	cf. EC 2.7.7.1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	cultured dorsal root ganglion neuron	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	Golgi fragmentation in cultured dorsal root ganglion neurons results in caspase dependent axon degeneration and neuronal cell death. NMNAT2 depletion in these neurons causes Golgi fragmentation and caspase dependent axon degeneration. NMNAT2 depletion does not cause ATP loss in the axons. Cytosolic Nmnat1 overexpression inhibits the axon degeneration induced by Golgi fragmentation or NMNAT2 depletion	Mus musculus

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Release 2023.1 (January 2023)