Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphate | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-diphosphoglycerate | 30% inhibition at 1 mM; competitive to D-ribose 5-phosphate | Homo sapiens | |
2-deoxy-D-ribose 5-phosphate | 92% inhibition at 1 mM | Homo sapiens | |
5-phospho-alpha-D-ribose 1-diphosphate | competitive to ribose 5-phosphate | Homo sapiens | |
adenosine | 27% inhibition at 1 mM | Homo sapiens | |
ADP | 99% inhibition at 1 mM; competitive inhibition to ATP; end product inhibition; the most effective | Homo sapiens | |
allopurinol ribonucleotides | 23% inhibition at 1 mM | Homo sapiens | |
AMP | 69% inhibition at 1 mM | Homo sapiens | |
CDP | 44% inhibition at 1 mM | Homo sapiens | |
CTP | 40% inhibition at 1 mM | Homo sapiens | |
D-fructose 1,6-diphosphate | 20% inhibition at 1 mM | Homo sapiens | |
D-Fructose 1-phosphate | 19% inhibition at 1 mM | Homo sapiens | |
D-ribose 1-phosphate | 13% inhibition at 1 mM | Homo sapiens | |
FAD | 51% inhibition at 1 mM | Homo sapiens | |
GDP | - |
Homo sapiens | |
glyceraldehyde 3-phosphate | 14% inhibition at 1 mM | Homo sapiens | |
GMP | 27% inhibition at 1 mM | Homo sapiens | |
GTP | 51% inhibition at 1 mM | Homo sapiens | |
guanosine | 20% inhibition at 1 mM | Homo sapiens | |
IDP | 47% inhibition at 1 mM | Homo sapiens | |
IMP | 21% inhibition at 1 mM | Homo sapiens | |
ITP | 36% inhibition at 1 mM | Homo sapiens | |
additional information | inhibition by pair of inhibitors tested is not greater than the sum of the inhibition produced by each alone | Homo sapiens | |
NAD+ | 100% inhibition at 1 mM | Homo sapiens | |
NADH | 72% inhibition at 1 mM | Homo sapiens | |
NADPH | 100% inhibition at 1 mM | Homo sapiens | |
TDP | 100% inhibition at 1 mM | Homo sapiens | |
TTP | 47% inhibition at 1 mM | Homo sapiens | |
UDP | 10%-16% inhibition at 1 mM | Homo sapiens | |
UMP | 10%-18% inhibition at 1 mM | Homo sapiens | |
XDP | 36% inhibition at 1 mM | Homo sapiens | |
XTP | 22% inhibition at 1 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
Mg2+ | pH 7.4, 37ºC | Homo sapiens | |
0.014 | - |
ATP | pH 7.4, 37ºC | Homo sapiens | |
0.014 | - |
ATP | ATP in form of MgATP2- | Homo sapiens | |
0.033 | - |
ribose 5-phosphate | pH 7.4, 37ºC | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-ribose 5-phosphate | Homo sapiens | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial, 400fold purification | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate | ordered bi-bi reaction with ribose-5-phosphate binding first and 5-phosphoribose diphosphate being released last | Homo sapiens | |
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate | ordered bi-bi reaction | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-ribose 5-phosphate | - |
Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Homo sapiens | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
5-phospho-alpha-D-ribose 1-diphosphate | pH 7.4, 37ºC | Homo sapiens | |
0.3 | - |
AMP | pH 7.4, 37ºC, with D-ribose-5-phosphate | Homo sapiens | |
0.4 | - |
AMP | pH 7.4, 37ºC, with MgATP2- | Homo sapiens |