Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H2O2 | H2O2 as low as 0.1 mM dramatically reduces enzymatic activity | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.4 | - |
ATP | pH and temperature not specified in the publication | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol hexakisphosphate | - |
Rattus norvegicus | ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate | - |
? | |
additional information | isoforms IP6K1 and IP6K2 bind to AP3B1protein | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol hexakisphosphate kinase | - |
Rattus norvegicus |
IP6K | - |
Rattus norvegicus |
IP6K1 | isoform | Rattus norvegicus |
IP6K2 | isoform | Rattus norvegicus |
IP6K3 | isoform | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of isoform IP6K2 prevents the apoptotic actions of interferon beta and gamma-irradiation and cisplatin in different cancer cell lines | Rattus norvegicus |
physiological function | isoform IP6K2 plays a specific role in regulating cell death. Isoform IP6K2 overexpression, that causes 10 to 20fold increase in IP7 level, enhances cell death | Rattus norvegicus |