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Literature summary for 2.7.11.9 extracted from

  • Granero-Molto, F.; Sarmah, S.; ORear, L.; Spagnoli, A.; Abrahamson, D.; Saus, J.; Hudson, B.G.; Knapik, E.W.
    Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development (2008), J. Biol. Chem., 283, 20495-20504.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.9

Cloned(Commentary)

Cloned (Comment) Organism
gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBP in HEK-293 cells Danio rerio
gene COL4A3BP, located on chromosome 5, the gene product is alternatively spliced producing two protein isozymes: GPBP and GPBPDELTA26, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant isozyme GPBPDELTA26 in HEK-293 cells Danio rerio

Protein Variants

Protein Variants Comment Organism
additional information construction of antisense oligonucleotide-mediated loss-of-function and synthetic mRNA-based gain-of-function mutants. The loss-of-function phenotype is linked to cell death, evident primarily in the muscle of the somites, extensive loss of myelinated tracks, and brain edema, phenotype, overview Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [Goodpasture antigen-binding protein] Danio rerio the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV ADP + [Goodpasture antigen-binding phosphoprotein]
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 ?
additional information Danio rerio disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Danio rerio Q5M7Y0 GPBP; gene COL4A3BP
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Danio rerio Q5M7Y0 GPBPDELTA26; gene COL4A3BP
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Source Tissue

Source Tissue Comment Organism Textmining
additional information isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, GPBP is an important factor for normal skeletal muscle and brain development, overview Danio rerio
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additional information isozymes GPBP and GPBPDELTA26 are differentially expressed during development, isozymes function during embryogenesis, overview Danio rerio
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [Goodpasture antigen-binding protein] the Goodpasture antigen-binding protein is an atypical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen IV Danio rerio ADP + [Goodpasture antigen-binding phosphoprotein]
-
 ?
additional information disruption of the nonvesicular ceramide transport is detrimental to normal embryonic development of somites and brain because of increased apoptosis mediated by the CERT function of GBPB, but not GBPBDELT26, overview Danio rerio ?
-
 ?
additional information isozyme GPBP also function as ceramide transfer proteins, CERT Danio rerio ?
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 ?
additional information isozyme GPBPDELTA26 also functions as ceramide transfer protein, CERT Danio rerio ?
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 ?

Synonyms

Synonyms Comment Organism
GPBP
-
 Danio rerio
GPBPDELTA26
-
 Danio rerio

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Danio rerio