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Literature summary for 2.7.11.31 extracted from

  • Garcia-Roves, P.M.; Osler, M.E.; Holmstroem, M.H.; Zierath, J.R.
    Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle (2008), J. Biol. Chem., 283, 35724-35734.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
transgenic mice overexpressing either the wild-type or the R225Q mutant subunit and knock-out mice Mus musculus

Protein Variants

Protein Variants Comment Organism
R225Q gain-of-function mutation, overexpression of the AMPK gamma3 subunit mutant increases mitochondrial biogenesis in glycolytic skeletal muscle, which is associated with an increase in expression of the co-activator PGC-1alpha and several transcription factors that regulate mitochondrial biogenesis, including NRF-1, NRF-2, and TFAM. Succinate dehydrogenase is also increased in transversal skeletal muscle sections of white gastrocnemius muscle, independent of changes in fiber type composition Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
additional information gastrocnemius muscle Mus musculus
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skeletal muscle AMPK gamma3 subunit is specific Mus musculus
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Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
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 Mus musculus
AMPK
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 Mus musculus

General Information

General Information Comment Organism
physiological function overexpression or ablation of the AMPK gamma3 subunit does not appear to play a critical role in defining mitochondrial content in resting skeletal muscle. Skeletal muscle mitochondrial content is unaltered in AMPK gamma3-/- mice Mus musculus