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Literature summary for 2.7.11.31 extracted from

  • Li, C.; Keaney, J.F.
    AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease (2010), Curr. Opin. Pharmacol., 10, 111-115.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside AICAR, chronic AMPK activation with AICAR decreases blood pressure in rats displaying features of the insulin resistance syndrome Rattus norvegicus
metformin AMPK mediates the prevention of progression of heart failure by metformin. Protective effects of AMPK activation by metformin on cardiovascular disease Canis lupus familiaris
additional information diabetic rats treated with cilostazol, a selective inhibitor of phosphodiesterase 3, exhibit normalization of endothelial function that is linked to AMPK activation producing increased endothelial nitric oxide synthase activity and NO production. In the ischemic heart, both catalytic alpha1-isoform and alpha2-isoform of AMPK containing regulatory gamma1-isoform or gamma2-isoform are activated Rattus norvegicus

Application

Application Comment Organism
drug development AMPK represents an attractive therapeutic target for vascular disease treatment Mus musculus
drug development AMPK represents an attractive therapeutic target for vascular disease treatment Homo sapiens
drug development AMPK represents an attractive therapeutic target for vascular disease treatment Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
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-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
endothelial cell
-
 Rattus norvegicus
-
heart
-
 Mus musculus
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heart
-
 Canis lupus familiaris
-
heart ischemic heart Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Mus musculus
AMP-activated protein kinase
-
 Homo sapiens
AMP-activated protein kinase
-
 Rattus norvegicus
AMP-activated protein kinase
-
 Canis lupus familiaris
AMPK
-
 Mus musculus
AMPK
-
 Homo sapiens
AMPK
-
 Rattus norvegicus
AMPK
-
 Canis lupus familiaris
Snf1 homolog to mammalian AMPK Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction AMPK gamma2 mutations are associated with hypertrophic cardiomyopathy Homo sapiens
physiological function AMPK activation induces vasodilatation and blood flow regulation in wild-type mice and this effect is abolished in AMPKalpha1 knockout mice. Chronic activation of AMPK in vivo attenuates ROS-mediated c-Jun N-terminal kinase activation and endothelial dysfunction in response to angiotensin II, which is abrogated in mice lacking the endothelial isoform of AMPKalpha1 or peroxisome proliferator gamma coactivator-1alpha, a target of AMPK that controls mitochondrial biogenesis. AMPK-deficient mice demonstrate impairment in postischemic fatty acid oxidation. In the setting of systolic pressure overload, left ventricular hypertrophy ensues and AMPKalpha2 knockout mice exhibit significantly increased overload-induced ventricular hypertrophy and decreased left ventricular ejection fraction. Isolated hearts of AMPK-deleted mice show increased apoptosis and dysfunction after ischemia/reperfusion. Role of AMPK in regulation of apoptosis that is an important mechanism of heart failure Mus musculus
physiological function AMPK activation inhibits ICAM-1 mediated migration of lymphocytes across primary microvascular endothelial cells Rattus norvegicus
physiological function AMPK activation inhibits TNFa-stimulated leukocyte adhesion to aortic endothelial cells and ICAM-1 mediated migration of lymphocytes across primary microvascular endothelial cells Homo sapiens
physiological function plays a crucial role in carbon catabolite repression in yeast. cRKIN1 gene product from rye can rescue SNF1 mutation Saccharomyces cerevisiae