Literature summary for 2.7.11.31 extracted from

Gundewar, S.; Calvert, J.W.; Jha, S.; Toedt-Pingel, I.; Ji, S.Y.; Nunez, D.; Ramachandran, A.; Anaya-Cisneros, M.; Tian, R.; Lefer, D.J.
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure (2009), Circ. Res., 104, 403-411.

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Activating Compound

Activating Compound	Comment	Organism	Structure
metformin	improves cardiac structure and function, which is associated with increases in AMPK and endothelial nitric oxide synthase phosphorylation, as well as increased peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha expression in cardiac myocytes. Cardioprotective effects of metformin are ablated in mice lacking functional AMPK or nitric oxide synthase	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
cardiac-specific transgenic mice overexpressing a dominant-negative AMPKalpha2 subunit	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6J mice	-
Mus musculus C57/BL6J	-	C57BL/6J mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac myocyte	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
AMP-activated protein kinase	-	Mus musculus
AMPK	-	Mus musculus

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Release 2023.1 (January 2023)