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Literature summary for 2.7.11.31 extracted from

  • eshmukh, A.S.; Treebak, J.T.; Long, Y.C.; Viollet, B.; Wojtaszewski, J.F.; Zierath, J.R.
    Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling (2008), Mol. Endocrinol., 22, 1105-1112.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR Mus musculus
AMP
-
 Mus musculus
additional information phosphorylation at Thr172 activates the enzyme, the phosphorylation is activated by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information AMPK subunit alpha2 and gamma3 knockoout mice show reduced inhibition of mTOR phosphorylation/activation and reduced mTOR signaling, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus AMPK is an important energy-sensing protein in skeletal muscle, it inhibits mTOR signaling thereby inhibiting protein synthesis initiation via S6K1 and 4E-BP1, regulation system, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Thr172 activates the enzyme, the phosphorylation is activated by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle extensor digitorum longus muscle Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AMPK is an important energy-sensing protein in skeletal muscle, it inhibits mTOR signaling thereby inhibiting protein synthesis initiation via S6K1 and 4E-BP1, regulation system, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
adenosine 5'-monophosphate-activated protein kinase
-
 Mus musculus
AMP-activated protein kinase
-
 Mus musculus
AMPK
-
 Mus musculus