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Literature summary for 2.7.11.31 extracted from

  • Vadasz, I.; Dada, L.A.; Briva, A.; Trejo, H.E.; Welch, L.C.; Chen, J.; Toth, P.T.; Lecuona, E.; Witters, L.A.; Schumacker, P.T.; Chandel, N.S.; Seeger, W.; Sznajder, J.I.
    AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis (2008), J. Clin. Invest., 118, 752-762.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Rattus norvegicus
Calmodulin activation of AMPK is mediated by a CO2-triggered increase in intracellular Ca2+ concentration and Ca2+/calmodulin-dependent kinase kinase-beta, CaMKK-beta Rattus norvegicus
additional information phosphorylation of AMPK at Thr172 of the alpha-subunit activates the enzyme Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of HA-tagged AMPK in ATII cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of constitutively active AMPK leads to activation of PKC-zeta and promotes Na,K-ATPase endocytosis, downregulation of AMPK via adenoviral delivery of dominant-negative AMPK-alpha prevents CO2-induced Na,K-ATPase endocytosis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition or downregulation of AMPK via adenoviral delivery of dominant-negative AMPK-alpha prevents CO2-induced Na,K-ATPase endocytosis Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation of AMPK is mediated by a CO2-triggered increase in intracellular Ca2+ concentration and Ca2+/calmodulin-dependent kinase kinase-beta, CaMKK-beta Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus activation of AMPK leads to activation of PKC-zeta and promotes Na,K-ATPase endocytosis. AMPK mediates CO2-induced Na,K-ATPase endocytosis and alveolar epithelial dysfunction, which can be prevented with beta-adrenergic agonists and cAMP ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of AMPK at Thr172 of the alpha-subunit Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell alveolar epithelial type II cell, ATII cell Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of AMPK leads to activation of PKC-zeta and promotes Na,K-ATPase endocytosis. AMPK mediates CO2-induced Na,K-ATPase endocytosis and alveolar epithelial dysfunction, which can be prevented with beta-adrenergic agonists and cAMP Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
-
 Rattus norvegicus
AMPK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus