Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-deoxyglucose | blocks glucose utilization and increases the intracellular AMP concentration, activation is suppressed by compound C | Homo sapiens | |
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside | i.e. AICAR, an AMP-activated protein kinase specific activator | Homo sapiens | |
AMP | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of GST-fused constitutively active form of AMPK alpha1, residues 1-312, and of the kinase-dead mutant AMPK in HEK-193 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of the kinase-negative AMPK inhibits enzyme activation by 2-deoxyglucose | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
compound C | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Golgi-specific brefeldin A resistance factor 1] | Homo sapiens | phosphorylation at Thr1337 to induce disassembly of Golgi apparatus | ADP + [Golgi-specific brefeldin A resistance factor 1] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [Golgi-specific brefeldin A resistance factor 1] | phosphorylation at Thr1337 to induce disassembly of Golgi apparatus | Homo sapiens | ADP + [Golgi-specific brefeldin A resistance factor 1] phosphate | - |
? | |
ATP + [Golgi-specific brefeldin A resistance factor 1] | a guanine nucleotide exchange factor for the ADP-ribosylation factor family associated with the Golgi apparatus, phosphorylation at Thr1337, phosphorylation site identification by mutational analysis | Homo sapiens | ADP + [Golgi-specific brefeldin A resistance factor 1] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMP-activated protein kinase | - |
Homo sapiens |
AMPK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |