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Literature summary for 2.7.11.31 extracted from

  • Hawley, S.A.; Davison, M.; Woods, A.; Davies, S.P.; Beri, R.K.; Carling, D.; Hardie, D.G.
    Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase (1996), J. Biol. Chem., 271, 27879-27887.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
5'-AMP
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 1 * 63000 + 1 * 38000 + 1 * 35000, 3 subunits alpha, beta and gamma, SDS-PAGE Rattus norvegicus
38000
-
 1 * 63000 + 1 * 38000 + 1 * 35000, 3 subunits alpha, beta and gamma, SDS-PAGE Rattus norvegicus
63000
-
 1 * 63000 + 1 * 38000 + 1 * 35000, 3 subunits alpha, beta and gamma, SDS-PAGE Rattus norvegicus
190000
-
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C, can be stored in buffer containing 50% glycerol for up to a month Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?

Subunits

Subunits Comment Organism
heterotrimer 1 * 63000 + 1 * 38000 + 1 * 35000, 3 subunits alpha, beta and gamma, SDS-PAGE Rattus norvegicus