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Literature summary for 2.7.11.31 extracted from

  • Ingebritsen, T.S.; Parker, R.A.; Gibson, D.M.
    Regulation of liver hydroxymethylglutaryl-CoA reductase by a bicyclic phosphorylation system (1981), J. Biol. Chem., 256, 1138-1144.
    View publication on PubMed
Search for more literature for 2.7.11.31

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation by cGMP Rattus norvegicus
additional information no activation by cAMP Rattus norvegicus
additional information no activation by cIMP, cCMP Rattus norvegicus
Reductase kinase kinase activation, i.e. EC 2.7.1.110, in the presence of MgATP2- Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
protein phosphatase C
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol predominant Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement, actual substrate: MgATP2- Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)]
-
 Rattus norvegicus Wistar ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus