Application | Comment | Organism |
---|---|---|
medicine | a significant inverse correlation is observed between level of phospho-GSK-3beta at the time of reperfusion and the extent of myocardium infarction in heart, phospho-GSK-3beta is a determinant of myocardial tolerance against reperfusion-induced necrosis. Thus, GSK-3beta is a target of therapy for cardioprotection upon reperfusion. Inactivation of GSK-3beta by phosphorylation at Ser9 elevates the threshold for mitochondrial permeability transition pore opening, which reduces myocyte necrosis. | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + p53 | - |
Homo sapiens | ADP + p53 phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Homo sapiens |
GSK-3beta | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inactivation of glycogen synthase kinase-3beta suppresses mitochondrial permeability transition pore opening and protects cardiomyocytes | Homo sapiens |