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Literature summary for 2.7.11.26 extracted from

  • Guerra-Araiza, C.; Amorim, M.A.; Camacho-Arroyo, I.; Garcia-Segura, L.M.
    Effects of progesterone and its reduced metabolites, dihydroprogesterone and tetrahydroprogesterone, on the expression and phosphorylation of glycogen synthase kinase-3 and the microtubule-associated protein tau in the rat cerebellum (2007), Dev. Neurobiol., 67, 510-520.
    View publication on PubMed
Search for more literature for 2.7.11.26

Inhibitors

Inhibitors Comment Organism Structure
3alpha,5alpha-tetrahydroprogesterone decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus Rattus norvegicus
5alpha-dihydroprogesterone decreases only expression of GSK-3 beta in the cerebellum but not in the hypothalamus Rattus norvegicus
progesterone decreases expression and phosphorylation of GSK-3 beta in the cerebellum but not in the hypothalamus, regulation of tau expression and phosphorylation by progesterone may contribute to the hormonal regulation of cerebellar function by the modification of neuronal cytoskeleton Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar albino female rats
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Rattus norvegicus
-
additional information hippothalamus Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein PHF-1
-
 Rattus norvegicus ADP + protein PHF-1 phosphate
-
 ?
ATP + protein tau
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 Rattus norvegicus ADP + protein tau phosphate
-
 ?
ATP + protein tau-1
-
 Rattus norvegicus ADP + protein tau-1 phosphate
-
 ?
additional information does not phosphorylate tau at epitope Ser 262 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase 3beta
-
 Rattus norvegicus
GSK-3 beta
-
 Rattus norvegicus