Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | required for PKA activation | Homo sapiens | |
forskolin | forskolin specifically induces tau hyperphosphorylation by PKA at Ser214 resulting in increased phosphorylation at Ser199, Ser22, Ser396, and Ser404 in N2a/tau441 cells, forskolin has no effect on GSK-3 | Homo sapiens | |
additional information | mechanism transitory activation of tau phosphorylation by PKA in Alzheimer's disease, effects of durative incubation with activators, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Neuro2a cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Homo sapiens | 5874 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Homo sapiens | - |
ADP + O-phospho-[tau-protein] | - |
? | |
additional information | Homo sapiens | GSK3beta and PKA work coordinatedly on tau phosphorylation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | - |
Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | GSK3beta and PKA work coordinatedly on tau phosphorylation | Homo sapiens | ? | - |
? | |
additional information | GSK3beta, EC 2.7.11.1, and PKA, EC 2.7.11.11, catalyze tau phosphorylation in brain, but phosphorylation of glycogen synthase and other proteins in different tissues | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP-dependent protein kinase A | - |
Homo sapiens |
glycogen synthase kinase-3 | - |
Homo sapiens |
GSK-3 | - |
Homo sapiens |
More | see also EC 2.7.11.1 and EC 2.7.11.11 | Homo sapiens |
PKA | - |
Homo sapiens |
protein kinase-A | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |