Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation activates ERK | Danio rerio | |
additional information | the factors Sprouty1 and Sprouty2 are involved in ERK regulation, mechanism, phosphorylation activates ERK | vertebrata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | molecular mechanism of negative regulation of Ras/ERK signaling, Sef negatively regulates ERK phosphorylation by blocking dissocation of MEK and ERK | Danio rerio | |
additional information | molecular mechanism of negative regulation of Ras/ERK signaling, Sef negatively regulates ERK phosphorylation by blocking dissocation of MEK and ERK | vertebrata |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus | vertebrata | 5737 | - |
cytoplasm | ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus | Danio rerio | 5737 | - |
Golgi apparatus | ERK colocalizes with MEK and Sef | vertebrata | 5794 | - |
Golgi apparatus | ERK colocalizes with MEK and Sef | Danio rerio | 5794 | - |
nucleus | ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus, mechanism | vertebrata | 5634 | - |
nucleus | ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus, mechanism | Danio rerio | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | vertebrata | spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling | ? | - |
? | |
additional information | Danio rerio | spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
vertebrata | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation activates ERK | Danio rerio |
phosphoprotein | the MAPK is phosphorylated and activated in the MAPK signaling cascade by 2 mechanisms: 1. by MEKs, EC 2.7.11.25, docking at the ED domain or the CD domain of MAPKs, or 2. by MKK7, MLK, JNK or MKP-7 docking at the scaffolding protein JIP in the JNK signaling pathway | vertebrata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling | vertebrata | ? | - |
? | |
additional information | spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling | Danio rerio | ? | - |
? | |
phosphoprotein | the MAPK is regulated in the MAPK signaling cascade by 2 mechanisms: 1. by MEK, EC 2.7.11.25, docking at the allosteric ED domain or the CD domain of MAPKs, or 2. by MKK7, MLK, JNK or MKP-7 docking at the scaffolding protein JIP in the JNK signaling pathway | vertebrata | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK | - |
vertebrata |
ERK | - |
Danio rerio |
MAP kinase | - |
vertebrata |
MAPK | - |
vertebrata |