Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activated by dual phosphorylation at Thr and Tyr during the UV response. Ha-Ras partially activates JNK1 and potentiates the activation caused by UV | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation, JNK1 activation may play an important role in tumor promotion | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P45983 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + c-Jun activation domain | enzyme binds to the c-Jun transactivation domain and phosphorylates it on Ser63 and Ser73 | Homo sapiens | ADP + phosphorylated c-Jun activation domain | - |
? | |
additional information | JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation, JNK1 activation may play an important role in tumor promotion | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JNK1 | - |
Homo sapiens |
mitogen-activated protein kinase 8 | - |
Homo sapiens |