Application | Comment | Organism |
---|---|---|
medicine | targeting Plk1 might be a promising approach for cancer therapy | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T210D | hyperactive mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SBE13 | selective type II Plk1 inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylated by Aurora A | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | - |
Homo sapiens | - |
Detroit 562 cell | - |
Homo sapiens | - |
HCT-115 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
LN-229 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
SKW6.4 cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Plk1 | - |
Homo sapiens |
Polo-like kinase 1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
kinase assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000002 | - |
immunoprecipitated Plk1 from HeLa cells | Homo sapiens | SBE13 |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | overexpressed in various tumors | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Plk1 is a key regulator of mitosis | Homo sapiens |