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Literature summary for 2.7.11.21 extracted from

  • Chi, Y.H.; Haller, K.; Ward, M.D.; Semmes, O.J.; Li, Y.; Jeang, K.T.
    Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1) (2008), J. Biol. Chem., 283, 35834-35844.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.21

Protein Variants

Protein Variants Comment Organism
K82M Plk1 kinase-dead mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
GW843682X
-
 Homo sapiens
siRNA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
kinetochore
-
 Homo sapiens 776
-
spindle
-
 Homo sapiens 5819
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Homo sapiens
-
 ADP + phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Mad1 the results suggest that Plk1 is influential of Mad1 phosphorylation, Mad1, mitotic arrest deficiency protein 1 Homo sapiens ADP + phosphorylated Mad1
-
 ?
ATP + protein
-
 Homo sapiens ADP + phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
Plk1
-
 Homo sapiens
Polo-like kinase 1
-
 Homo sapiens